Study - NMN Impacts on Fertility

 A brand new study (30th September 2024) has shed light on the incredible potential of NMN supplementation in helping to combat age-related ovarian infertility

by improving the quality and quantity of eggs.

What did the study find?

This study found that levels of nicotinamide adenine dinucleotide (NAD+) in the ovaries

decrease with age, but NMN can restore these levels, preventing ovarian decline

and enhancing ovulated egg quality and quantity.

Additionally, NMN improves hormone secretion, boosts antioxidant levels,

and reduces inflammation. It also increases the number of ovarian follicles in older individuals. Microscopic analysis revealed that NMN positively affects the structure of lipid droplets

and mitochondria in cells.

Overall, NMN appears to improve mitochondrial function, energy metabolism,

and inflammation in aging ovaries, suggesting it could enhance ovarian health

and reserve, offering new avenues for addressing fertility issues

in older women through assisted reproductive technology.

What is the significance?

Female fertility involves a woman's ability to produce eggs, undergo fertilisation,

and carry a pregnancy. It typically peaks around age 24, declines after 30,

and drops more sharply after 37.

Most women experience a natural decrease in fertility about 10 years before menopause,

with complete depletion of egg reserves around age 50.

Ovarian aging is the primary reason for reduced fertility in older women,

leading to a decrease in both the number and quality of ovarian follicles,

as well as diminished hormonal function.

Although assisted reproductive technology (ART) can help couples achieve pregnancy,

advanced maternal age complicates this due to the reduced quantity

and quality of eggs, making successful outcomes harder to attain.

This study shows that long-term supplementation with NMN can potentially

enhance ovarian health, and therefore, fertility.

We do need to note that this study was done on mice and for part of it,

the amount of NMN administered was very high, due to the timescale of the study,

but we are incredibly excited about the potential implications of this study.